Diverse cellular actions of tert-butylhydroquinone, a food additive, on rat thymocytes
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چکیده
منابع مشابه
tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand.
In contrast to the beneficial effects of tert-butylhydroquinone (tBHQ) as a food antioxidant, a number of studies have shown that chronic exposure to tBHQ may induce carcinogenicity. Therefore, we examined the ability of tBHQ to induce the cytochrome P450 1a1 (Cyp1a1), an enzyme known to play an important role in the chemical activation of xenobiotics to carcinogenic derivatives. A significant ...
متن کاملRegulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone.
CYP1A1, a major phase I enzyme, plays an important role in the metabolism of polycyclic aromatic hydrocarbons and in the chemical activation of xenobiotics to carcinogenic derivatives. The phenolic antioxidant tert-butylhydroquinone (tBHQ), often used as a food preservative, is generally considered to act only as a mono-functional inducer of phase II enzymes, thereby exerting chemo-protection. ...
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considering that the involvement of oxidative stress has been implicated in the toxicity of organophosphate insecticides, the objective of the present study was to investigate antioxidants and oxidative stress markers in the liver and kidney of wistar rats treated with chronic doses of diazinon. in addition, the effect of tert-butylhydroquinone (tbhq), a food-additive antioxidant, on attenuatio...
متن کاملEffects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice
Traumatic brain injury (TBI) can induce intestinal inflammatory response and mucosal injury. Antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown in our previous studies to prevent oxidative stress and inflammatory response in gut after TBI. The objective of this study was to test whether tert-butylhydroquinone (tBHQ), an Nrf2 inducer, can protect a...
متن کاملPreventive effect of tert-butylhydroquinone on scrotal heat-induced damage in mouse testes.
To investigate the effect of tert-butylhydroquinone (tBHQ) on scrotal heat-induced damage in mice testes, 8-week-old mice were divided into 6 groups and administered with or without tBHQ through diet (10 mg/g), intraperitoneal injection (100 mg/kg body weight), or intratestis injection (12.5 mg/kg body weight), respectively. After single scrotal heat exposure (42 °C for 25 min), trunk blood and...
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ژورنال
عنوان ژورنال: Toxicol. Res.
سال: 2017
ISSN: 2045-452X,2045-4538
DOI: 10.1039/c7tx00183e